Most of the weapons originally appeared in one of the previous games:
- OmniWrench 8000: Ratchet & Clank (PS2)
- Pyrocitor: Ratchet & Clank (PS2)
- Glove of Doom: Ratchet & Clank (PS2)
- Sheepinator: Ratchet & Clank 2
- Bouncer and Heavy Bouncer: Ratchet & Clank 2
- Omega Heavy Bouncer: Ratchet & Clank 3
- Fusion Grenade and Fusion Bomb and Omega Fusion Bomb: Tools of Destruction
- Combustor: Tools of Destruction
- Predator Launcher and Raptor Launcher and Omega Raptor Launcher: Tools of Destruction
- Buzz Blades and Doom Blades and Omega Doom Blades: Tools of Destruction
- Groovitron: Tools of Destruction (as a device) / A Crack in Time (as a weapon: "Groovitron Glove" ammo)
- Groovibomb and Omega Groovibomb: A Crack in Time (as; "Groovibomb Glove" ammo)
- Mr. Zurkon: Tools of Destruction (as a device) / A Crack in Time (as a weapon)
- Zurkon Jr.: Into the Nexus
- Plasma Striker and Plasma Slayer and Omega Plasma Slayer: A Crack in Time
- Warmonger: All 4 One
- Peacemaker and Omega Peacemaker: Into the Nexus
The game does have several new weapons however
- Lavacitor and Omega Lavacitor
- Apocalypse Glove and Omega Apocalypse Glove
- Goatinator and Omega Goatinator
- Magmabustor and Omega Magmabustor
- Omega Zurkon Jr.
- Proton Drum and Protoclast and Omega Protoclast
- Pixelizer and Pixeliser HD and Omega Pixeliser HD
- RYNO (new PS4 version) and RYNO Xtreme! and Omega RYNO Xtreme!!!
The game does not feature a single weapon that made it's debut in
Ratchet: Gladiator,
Quest for Booty, or
QForce outside of holocard appearances.